Ralimetinib
Modify Date: 2024-01-03 16:45:19
Ralimetinib structure
|
Common Name | Ralimetinib | ||
|---|---|---|---|---|
| CAS Number | 862505-00-8 | Molecular Weight | 420.53 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 634.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H29FN6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 337.5±34.3 °C | |
Use of RalimetinibRalimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc[1]. |
| Name | 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine |
|---|---|
| Synonym | More Synonyms |
| Description | Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc[1]. |
|---|---|
| Related Catalog | |
| Target |
p38β MAPK:3.2 nM (IC50) p38α MAPK:5.3 nM (IC50) |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 634.4±65.0 °C at 760 mmHg |
| Molecular Formula | C24H29FN6 |
| Molecular Weight | 420.53 |
| Flash Point | 337.5±34.3 °C |
| Exact Mass | 420.243774 |
| PSA | 86.14000 |
| LogP | 4.94 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.631 |
|
~74%
Ralimetinib CAS#:862505-00-8 |
| Literature: ELI LILLY AND COMPANY Patent: WO2005/75478 A1, 2005 ; Location in patent: Page/Page column 49 ; WO 2005/075478 A1 |
|
~59%
Ralimetinib CAS#:862505-00-8 |
| Literature: ELI LILLY AND COMPANY Patent: WO2005/75478 A1, 2005 ; Location in patent: Page/Page column 55-56 ; WO 2005/075478 A1 |
![{6-[2-tert-butyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-3-nitro-pyridin-2-yl}-(2,2-dimethyl-propyl)-amine structure](https://www.chemsrc.com/caspic/417/862507-55-9.png)
![1-[2-amino-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-5-yl]-2-(4-fluorophenyl)ethane-1,2-dione structure](https://www.chemsrc.com/caspic/231/862507-91-3.png)
| UNII-73I34XW4HD |
| 5-[2-tert-butyl-5-(4-fluoro-phenyl)-1H-imidazol-4-yl]-3-(2,2-dimethyl-propyl)-3H-imidazo[4,5-b]pyridin-2-ylamine |
| Ralimetinib |
| 3-(2,2-Dimethylpropyl)-5-[4-(4-fluorophenyl)-2-(2-methyl-2-propanyl)-1H-imidazol-5-yl]-3H-imidazo[4,5-b]pyridin-2-amine |
| LY2228820 |
| 5-(2-(tert-butyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine |
| 3H-Imidazo[4,5-b]pyridin-2-amine, 5-[2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)- |