KMG-104

Modify Date: 2024-01-08 00:18:49

KMG-104 Structure
KMG-104 structure
Common Name KMG-104
CAS Number 852057-94-4 Molecular Weight 435.33
Density N/A Boiling Point N/A
Molecular Formula C23H11F2NO6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of KMG-104


KMG-104 is a highly selective fluorescent Mg2+ probe. KMG-104 has been used widely and revealed Mg2+ mobilization in cytoplasm in various types of cells[1].

 Names

Name kmg-104
Synonym More Synonyms

 KMG-104 Biological Activity

Description KMG-104 is a highly selective fluorescent Mg2+ probe. KMG-104 has been used widely and revealed Mg2+ mobilization in cytoplasm in various types of cells[1].
Related Catalog
In Vitro KMG-104 is useful for confocal laser scanning microscopy because it is excited at 490 nm, and emitted fluorescence around 510 nm. Fluorescent intensity of KMG-104 increases with [Mg] increase, and it shows no response to Na, K, and Ca; the dissociation constant (Kd) for Mg is 3 mM. KMG-104 is able to trace only [Mg] change inphysiological conditions[2]. PC12 cells are loaded with a novel Mg indicator KMG-104 and Ca indicator fura-2, and intracellular Mg is studied in the endoplasmic reticulums (ERs), mitochondria, and Mg-ATP[2].
References

[1]. Kubota T, et al. Investigation of intracellular magnesium mobilization pathways I PC12 cells B simultaneous Mg-Ca fluorescent imaging. J Am Coll Nutr. 2004;23(6):742S-4S.

[2]. Fujii T, et al. Design and synthesis of a FlAsH-type Mg2+ fluorescent probe for specific protein labeling. J Am Chem Soc. 2014;136(6):2374-2381.

 Chemical & Physical Properties

Molecular Formula C23H11F2NO6
Molecular Weight 435.33
Exact Mass 435.05500
PSA 109.22000
LogP 3.85970

 Synonyms

1-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic acid
1-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic acid