(R)-ADX-47273

Modify Date: 2025-09-21 23:52:51

(R)-ADX-47273 Structure
(R)-ADX-47273 structure
Common Name (R)-ADX-47273
CAS Number 851881-59-9 Molecular Weight 369.36
Density N/A Boiling Point N/A
Molecular Formula C20H17F2N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (R)-ADX-47273


(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .

 Names

Name (R)-ADX-47273

 (R)-ADX-47273 Biological Activity

Description (R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
Related Catalog
Target

mGluR5:168 nM (EC50)

In Vitro (R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM[1].
References

[1]. Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4(4):505-11.

 Chemical & Physical Properties

Molecular Formula C20H17F2N3O2
Molecular Weight 369.36
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