Zatebradine
Modify Date: 2025-08-27 07:54:52
Zatebradine structure
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Common Name | Zatebradine | ||
|---|---|---|---|---|
| CAS Number | 85175-67-3 | Molecular Weight | 456.57400 | |
| Density | 1.115g/cm3 | Boiling Point | 612.5ºC at 760 mmHg | |
| Molecular Formula | C26H36N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 324.3ºC | |
Use of ZatebradineZatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM.IC50 value: 10 uM(92% 92% inhibition of the hHCN1) [1]Target: hHCN channel antagonistThe pharmacological properties of hHCN1-mediated currents resembled those of native hyperpolarization-activated currents (I(h)), that is, blockade by Cs(+) (99% at 5 mm), ZD 7288 (98% at 100 microm) and zatebradine (92% at 10 microm) [1]. When voltage-clamp pulse trains were applied, cilobradine induced a use-dependent blockade of If that was stronger and faster than that with zatebradine. Recovery from blockade during prolonged hyperpolarization was significantly faster with zatebradine [2]. The selective HCN blocker zatebradine reduced the activity of oriens-lacunosum moleculare interneurons in wild-type but not HCN2(-/-) mice and decreased the frequency of spontaneous inhibitory currents in postsynaptic CA1 pyramidal cells [3]. |
| Name | 3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one |
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| Synonym | More Synonyms |
| Description | Zatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM.IC50 value: 10 uM(92% 92% inhibition of the hHCN1) [1]Target: hHCN channel antagonistThe pharmacological properties of hHCN1-mediated currents resembled those of native hyperpolarization-activated currents (I(h)), that is, blockade by Cs(+) (99% at 5 mm), ZD 7288 (98% at 100 microm) and zatebradine (92% at 10 microm) [1]. When voltage-clamp pulse trains were applied, cilobradine induced a use-dependent blockade of If that was stronger and faster than that with zatebradine. Recovery from blockade during prolonged hyperpolarization was significantly faster with zatebradine [2]. The selective HCN blocker zatebradine reduced the activity of oriens-lacunosum moleculare interneurons in wild-type but not HCN2(-/-) mice and decreased the frequency of spontaneous inhibitory currents in postsynaptic CA1 pyramidal cells [3]. |
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| Related Catalog | |
| References |
| Density | 1.115g/cm3 |
|---|---|
| Boiling Point | 612.5ºC at 760 mmHg |
| Molecular Formula | C26H36N2O5 |
| Molecular Weight | 456.57400 |
| Flash Point | 324.3ºC |
| Exact Mass | 456.26200 |
| PSA | 60.47000 |
| LogP | 3.15070 |
| Index of Refraction | 1.545 |
| Storage condition | 2-8℃ |
| Precursor 10 | |
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| DownStream 0 | |
![1-[7,8dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane Structure](https://image.chemsrc.com/caspic/218/85175-60-6.png)
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CAS#:36770-74-8![7,8-Dimethoxy-1,3,4,5-tetrahydrobenzo[d]azepin-2-one Structure](https://image.chemsrc.com/caspic/000/20925-64-8.png)
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CAS#:10313-60-7| Zatebradinum [INN-Latin] |
| UL-FS-49 |
| 3-[3-[(3,4-Dimethoxy phenethyl)methylamino]-propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one |
| Zatebradina |
| Zatebradine |
| Zatebradine [INN] |
| 7,8-dimethoxy-3-<3-<<2-(3,4-dimethoxyphenyl)ethyl>-methylamino>propyl>-1,3,4,5-tetrahydro-2H-benzazepin-2-one |
| Zatebradina [INN-Spanish] |
| Zatebradinum |
| [14C]-Zatebradine |
| 1-[7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}ethyl)-amino]-propane |