2,5-Difluorobenzyl bromide

Modify Date: 2024-01-08 20:24:23

2,5-Difluorobenzyl bromide Structure
2,5-Difluorobenzyl bromide structure
Common Name 2,5-Difluorobenzyl bromide
CAS Number 85117-99-3 Molecular Weight 207.015
Density 1.6±0.1 g/cm3 Boiling Point 187.9±25.0 °C at 760 mmHg
Molecular Formula C7H5BrF2 Melting Point 8ºC
MSDS Chinese USA Flash Point 15.6±0.0 °C
Symbol GHS02 GHS05
GHS02, GHS05
Signal Word Danger

 Names

Name 2,5-Difluorobenzyl bromide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 187.9±25.0 °C at 760 mmHg
Melting Point 8ºC
Molecular Formula C7H5BrF2
Molecular Weight 207.015
Flash Point 15.6±0.0 °C
Exact Mass 205.954269
LogP 3.09
Vapour Pressure 0.8±0.3 mmHg at 25°C
Index of Refraction 1.523
Storage condition Flammables area

 Safety Information

Symbol GHS02 GHS05
GHS02, GHS05
Signal Word Danger
Hazard Statements H225-H314
Precautionary Statements P210-P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes F:Flammable;C:Corrosive;
Risk Phrases R11;R22;R34
Safety Phrases S26-S36/37/39-S45-S16
RIDADR UN 2924 3/PG 2
WGK Germany 3
Packaging Group III
Hazard Class 8

 Synthetic Route

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2,5-Difluorobenzyl bromide Structure

2,5-Difluoroben...

CAS#:85117-99-3

Literature: Journal of Medicinal Chemistry, , vol. 31, # 5 p. 1005 - 1009

 Articles2

More Articles
Aryl sulfones: a new class of gamma-secretase inhibitors.

Bioorg. Med. Chem. Lett. 15(10) , 2685-8, (2005)

The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.

Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.

Bioorg. Med. Chem. Lett. 21 , 1880-1886, (2011)

A series of 4-amino cyclohexanes and 4-substituted piperidines were prepared and evaluated for inhibition of DPP-4. Analog 20q displayed both good DPP-4 potency and selectivity against other proteases...

 Synonyms

2,5-Difluorobenzyl bromide
α-Bromo-2,5-difluorotoluene
2-(Bromomethyl)-1,4-difluorobenzene
Benzene, 2-(bromomethyl)-1,4-difluoro-
EINECS 285-651-0
FR DF B1E
MFCD00009897