2,5-Difluorobenzyl bromide
Names
[ CAS No. ]:
85117-99-3
[ Name ]:
2,5-Difluorobenzyl bromide
[Synonym ]:
2,5-Difluorobenzyl bromide
α-Bromo-2,5-difluorotoluene
2-(Bromomethyl)-1,4-difluorobenzene
Benzene, 2-(bromomethyl)-1,4-difluoro-
EINECS 285-651-0
FR DF B1E
MFCD00009897
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
187.9±25.0 °C at 760 mmHg
[ Melting Point ]:
8ºC
[ Molecular Formula ]:
C7H5BrF2
[ Molecular Weight ]:
207.015
[ Flash Point ]:
15.6±0.0 °C
[ Exact Mass ]:
205.954269
[ LogP ]:
3.09
[ Vapour Pressure ]:
0.8±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.523
[ Storage condition ]:
Flammables area
MSDS
Safety Information
[ Symbol ]:
GHS02, GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H314
[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable;C:Corrosive;
[ Risk Phrases ]:
R11;R22;R34
[ Safety Phrases ]:
S26-S36/37/39-S45-S16
[ RIDADR ]:
UN 2924 3/PG 2
[ WGK Germany ]:
3
[ Packaging Group ]:
III
[ Hazard Class ]:
8
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Bioorg. Med. Chem. Lett. 15(10) , 2685-8, (2005)
The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.Bioorg. Med. Chem. Lett. 21 , 1880-1886, (2011)
A series of 4-amino cyclohexanes and 4-substituted piperidines were prepared and evaluated for inhibition of DPP-4. Analog 20q displayed both good DPP-4 potency and selectivity against other proteases...