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2,5-Difluorobenzyl bromide

Names

[ CAS No. ]:
85117-99-3

[ Name ]:
2,5-Difluorobenzyl bromide

[Synonym ]:
2,5-Difluorobenzyl bromide
α-Bromo-2,5-difluorotoluene
2-(Bromomethyl)-1,4-difluorobenzene
Benzene, 2-(bromomethyl)-1,4-difluoro-
EINECS 285-651-0
FR DF B1E
MFCD00009897

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
187.9±25.0 °C at 760 mmHg

[ Melting Point ]:
8ºC

[ Molecular Formula ]:
C7H5BrF2

[ Molecular Weight ]:
207.015

[ Flash Point ]:
15.6±0.0 °C

[ Exact Mass ]:
205.954269

[ LogP ]:
3.09

[ Vapour Pressure ]:
0.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.523

[ Storage condition ]:
Flammables area

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H314

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable;C:Corrosive;

[ Risk Phrases ]:
R11;R22;R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S16

[ RIDADR ]:
UN 2924 3/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

Synthetic Route

Precursor & DownStream

Articles

Aryl sulfones: a new class of gamma-secretase inhibitors.

Bioorg. Med. Chem. Lett. 15(10) , 2685-8, (2005)

The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.

Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.

Bioorg. Med. Chem. Lett. 21 , 1880-1886, (2011)

A series of 4-amino cyclohexanes and 4-substituted piperidines were prepared and evaluated for inhibition of DPP-4. Analog 20q displayed both good DPP-4 potency and selectivity against other proteases...


More Articles


Related Compounds