Bioorganic & Medicinal Chemistry Letters 2005-05-16

Aryl sulfones: a new class of gamma-secretase inhibitors.

Martin Teall, Paul Oakley, Timothy Harrison, Duncan Shaw, Euan Kay, Jason Elliott, Ute Gerhard, José L Castro, Mark Shearman, Richard G Ball, Nancy N Tsou

Index: Bioorg. Med. Chem. Lett. 15(10) , 2685-8, (2005)

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Abstract

The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.