Niperotidine

Modify Date: 2025-09-18 11:14:56

Use of Niperotidine

Niperotidine is a histamine H2-receptor antagonist.

Name	N-(1,3-benzodioxol-5-ylmethyl)-N'-[2-[[5-[(dimethylamino)methyl]furfuryl]thio]ethyl]-2-nitrovinylidenediamine
Synonym	More Synonyms

Description	Niperotidine is a histamine H2-receptor antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Metabolic Disease
Target	histamine H2 receptor[1]
In Vivo	Niperotidine (piperonyl-ranitidine) is a H2 blocking agent. Niperotidine is a H2-receptor antagonist structurally related to ranitidine. After oral administration, it reaches a plasmatic peak within 60-120 min and is eliminates either in the urine or in the faeces, with an enterohepatic circulation[2].
References	[1]. Palasciano G, et al. The effect of the H2-antagonist Niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Ital J Gastroenterol. 1990 Oct;22(5):291-4. [2]. Gasbarrini G, et al. Acute liver injury related to the use of Niperotidine. J Hepatol. 1997 Sep;27(3):583-6.

Density	1.268g/cm3
Boiling Point	566.324ºC at 760 mmHg
Molecular Formula	C₂₀H₂₆N₄O₅S
Molecular Weight	434.50900
Flash Point	296.302ºC
Exact Mass	434.16200
PSA	130.02000
LogP	4.06310
Index of Refraction	1.591
InChIKey	HXRSXEDVVARPHP-UHFFFAOYSA-N
SMILES	CN(C)Cc1ccc(CSCCNC(=C[N+](=O)[O-])NCc2ccc3c(c2)OCO3)o1
Storage condition	2-8℃

Niperotidine

Piperotidine

N-(1,3-Benzodioxol-5-ylmethyl)-N'-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-2-nitro-1,1-ethenediamine

Piperonylranitidine

PiperotidineHCl

Piperonylranitidinehydrochloride

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Price: $588/1mg

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