Niperotidine

Names

[ Name ]:
Niperotidine

[Synonym ]:
Niperotidine
Piperotidine
N-(1,3-Benzodioxol-5-ylmethyl)-N'-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-2-nitro-1,1-ethenediamine
Piperonylranitidine
PiperotidineHCl
Piperonylranitidinehydrochloride

Biological Activity

[Description]:

Niperotidine is a histamine H2-receptor antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Metabolic Disease

[Target]

histamine H2 receptor[1]

[In Vivo]

Niperotidine (piperonyl-ranitidine) is a H2 blocking agent. Niperotidine is a H2-receptor antagonist structurally related to ranitidine. After oral administration, it reaches a plasmatic peak within 60-120 min and is eliminates either in the urine or in the faeces, with an enterohepatic circulation[2].

[References]

[1]. Palasciano G, et al. The effect of the H2-antagonist Niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Ital J Gastroenterol. 1990 Oct;22(5):291-4.

[2]. Gasbarrini G, et al. Acute liver injury related to the use of Niperotidine. J Hepatol. 1997 Sep;27(3):583-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.268g/cm3

[ Boiling Point ]:
566.324ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₆N₄O₅S

[ Molecular Weight ]:
434.50900

[ Flash Point ]:
296.302ºC

[ Exact Mass ]:
434.16200

[ PSA ]:
130.02000

[ LogP ]:
4.06310

[ Index of Refraction ]:
1.591

[ Storage condition ]:
2-8℃

Related Compounds

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