G3-C12

Modify Date: 2024-01-14 18:09:47

G3-C12 Structure
G3-C12 structure
Common Name G3-C12
CAS Number 848301-94-0 Molecular Weight 1758.98
Density N/A Boiling Point N/A
Molecular Formula C74H115N23O23S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of G3-C12


G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.

 Names

Name G3-C12

 G3-C12 Biological Activity

Description G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.
Related Catalog
Target

Kd: 88 nM (Galectin-3)[1]

In Vitro G3-C12 is a galectin-3 binding peptide, with high affinity (Kd) of 88 nM, but shows no affinity for other galectin family members or to other lectins. G3-C12 bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer[1].
References

[1]. Kopansky E, et al. Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer. J Drug Target. 2011 Dec;19(10):933-43.

 Chemical & Physical Properties

Molecular Formula C74H115N23O23S2
Molecular Weight 1758.98
Storage condition 2-8℃