848301-94-0

848301-94-0 structure

Name: G3-C12
Chemical Name: G3-C12
CAS Number: 848301-94-0
Molecular Formula: C₇₄H₁₁₅N₂₃O₂₃S₂
Molecular Weight: 1758.98
Catalog: Peptides
Create Date: 2018-09-10 04:35:01
Modify Date: 2024-01-14 18:09:47
G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.

Name	G3-C12

Description	G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Cancer
Target	Kd: 88 nM (Galectin-3)[1]
In Vitro	G3-C12 is a galectin-3 binding peptide, with high affinity (Kd) of 88 nM, but shows no affinity for other galectin family members or to other lectins. G3-C12 bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer[1].
References	[1]. Kopansky E, et al. Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer. J Drug Target. 2011 Dec;19(10):933-43.