lamotrigine

Modify Date: 2025-08-21 09:55:09

lamotrigine structure	Common Name	lamotrigine
	CAS Number	84057-84-1	Molecular Weight	256.091
	Density	1.6±0.1 g/cm3	Boiling Point	503.1±60.0 °C at 760 mmHg
	Molecular Formula	C₉H₇Cl₂N₅	Melting Point	177-181°C
	MSDS	Chinese USA	Flash Point	258.1±32.9 °C
	Symbol	GHS06	Signal Word	Danger

Use of lamotrigine

Lamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channelTarget: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate [1]. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected [2]. Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels [3]. Lamotrigine (Lamictal), a phenyltriazine derivative, is a well established anticonvulsant agent that has shown efficacy in the prevention of mood episodes in adult patients with bipolar I disorder. lamotrigine significantly delayed time to intervention for a depressive episode and showed limited efficacy in delaying time to intervention for a manic/hypomanic episode, compared with placebo. Lamotrigine is generally well tolerated [4].

Name	lamotrigine
Synonym	More Synonyms

Description	Lamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channelTarget: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate [1]. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected [2]. Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels [3]. Lamotrigine (Lamictal), a phenyltriazine derivative, is a well established anticonvulsant agent that has shown efficacy in the prevention of mood episodes in adult patients with bipolar I disorder. lamotrigine significantly delayed time to intervention for a depressive episode and showed limited efficacy in delaying time to intervention for a manic/hypomanic episode, compared with placebo. Lamotrigine is generally well tolerated [4].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
References	[1]. Goa, K.L., S.R. Ross, and P. Chrisp, Lamotrigine. A review of its pharmacological properties and clinical efficacy in epilepsy. Drugs, 1993. 46(1): p. 152-76. [2]. Leach, M.J., C.M. Marden, and A.A. Miller, Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia, 1986. 27(5): p. 490-7. [3]. Cheung, H., D. Kamp, and E. Harris, An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res, 1992. 13(2): p. 107-12. [4]. Goldsmith, D.R., et al., Lamotrigine: a review of its use in bipolar disorder. Drugs, 2003. 63(19): p. 2029-50.

Description

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

References

[1]. Goa, K.L., S.R. Ross, and P. Chrisp, Lamotrigine. A review of its pharmacological properties and clinical efficacy in epilepsy. Drugs, 1993. 46(1): p. 152-76.

[2]. Leach, M.J., C.M. Marden, and A.A. Miller, Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia, 1986. 27(5): p. 490-7.

[3]. Cheung, H., D. Kamp, and E. Harris, An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res, 1992. 13(2): p. 107-12.

[4]. Goldsmith, D.R., et al., Lamotrigine: a review of its use in bipolar disorder. Drugs, 2003. 63(19): p. 2029-50.

Density	1.6±0.1 g/cm3
Boiling Point	503.1±60.0 °C at 760 mmHg
Melting Point	177-181°C
Molecular Formula	C₉H₇Cl₂N₅
Molecular Weight	256.091
Flash Point	258.1±32.9 °C
Exact Mass	255.007858
PSA	90.71000
LogP	-0.19
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.706
Storage condition	2-8°C
Water Solubility	DMSO: 20 mg/mL at 60 °C, soluble

lamotrigine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY5850700

CHEMICAL NAME :: 1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-

CAS REGISTRY NUMBER :: 84057-84-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H7-Cl2-N5

MOLECULAR WEIGHT :: 256.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Sense Organs and Special Senses (Eye) - effect, not otherwise specified Cardiac - EKG changes not diagnostic of specified effects

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 342,1552,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2 mg/kg/30H-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 98,294,1996

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 205 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959- Volume(issue)/page/year: 25,655,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959- Volume(issue)/page/year: 25,655,1984

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R25
Safety Phrases	S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	XY5850700
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933699090

2-(2,3-Dichloro...

CAS#:84689-20-3

~82%

lamotrigine

CAS#:84057-84-1

Literature: ALEMBIC LIMITED Patent: WO2009/69073 A1, 2009 ; Location in patent: Page/Page column 3; 5 ;

benzonitrile, d...

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Aminoguanidine ...

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lamotrigine

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Literature: US4847249 A1, ;

2,3-Dichloroben...

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lamotrigine

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Literature: US6111101 A1, ;

1-Propanol

CAS#:71-23-8

benzonitrile, d...

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Aminoguanidine ...

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lamotrigine

CAS#:84057-84-1

Literature: EP247892 B1, ;

6-(2,3-dichloro...

CAS#:879573-84-9

~76%

lamotrigine

CAS#:84057-84-1

Literature: Ulomskii; Shestakova; Deev; Rusinov; Chupakhin Russian Chemical Bulletin, 2005 , vol. 54, # 3 p. 726 - 732

2,3-dihlorophen...

CAS#:130801-01-3

lamotrigine

CAS#:84057-84-1

Literature: Russian Chemical Bulletin, , vol. 54, # 3 p. 726 - 732

DICHLOROTOLUENE

CAS#:32768-54-0

lamotrigine

CAS#:84057-84-1

Literature: Russian Chemical Bulletin, , vol. 54, # 3 p. 726 - 732

2,3-Dichloroben...

CAS#:57915-78-3

lamotrigine

CAS#:84057-84-1

Literature: Russian Chemical Bulletin, , vol. 54, # 3 p. 726 - 732

Precursor 8
CAS#:84689-20-3 2-(2,3-Dichloro... CAS#:6574-97-6 benzonitrile, d... CAS#:2582-30-1 Aminoguanidine ... CAS#:77668-42-9 2,3-Dichloroben...
CAS#:71-23-8 1-Propanol CAS#:879573-84-9 6-(2,3-dichloro... CAS#:32768-54-0 DICHLOROTOLUENE CAS#:57915-78-3 2,3-Dichloroben...
DownStream 0

HS Code	2933699090
Summary	2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery.

PLoS ONE 10(1) , e0116766, (2015)

Acute and chronic pain conditions are often debilitating, inflicting severe physiological, emotional and economic costs and affect a large percentage of the global population. However, the development...

Development and validation of a GC/MS method for the simultaneous determination of levetiracetam and lamotrigine in whole blood.

J. Pharm. Biomed. Anal. 102 , 25-32, (2014)

A sensitive and accurate gas chromatography-mass spectrometric method was developed and validated for the simultaneous determination of levetiracetam and lamotrigine in whole blood. A solid-phase extr...

Functionalized nanocarrier combined seizure-specific vector with P-glycoprotein modulation property for antiepileptic drug delivery.

Biomaterials 74 , 64-76, (2015)

Despite optimal therapeutic regimen with currently available antiepileptic drugs (AEDs), approximately a third of epilepsy patients remain drug refractory. Region-specific overexpression of multidrug ...

Lamictal

Lamotrigin

6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine

EINECS 281-901-8

6-(2,3-Dichlorophenyl)-3-imino-3,4-dihydro-1,2,4-triazin-5-amine

1,2,4-Triazin-5-amine, 6-(2,3-dichlorophenyl)-3,4-dihydro-3-imino-

Crisomet

Lamictal CD

HYDROXYMETHYL PROGESTERONE

6-O-TRITYL-1,2,3,4-TETRA-O-ACETYL-ALPHA-D-MANNOPYRANOSE

BW 430C

LAMOTRIGENE

LAMOTRIGINE API

MFCD00865333

LAMOTRIGINE / 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZINE-3,5-DIAMINE

Lamictal XR

1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-

LAMOTRIGINE-13C3

LAMOTRIGINE (10 MG )

Lamotrigina

1,2,4-TRIAZINE-3,5-DIAMINE,6-(2,3-DICHLOROPHENYL)-

Labileno

Lamotriginum

Lamotrigine

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China
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China
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China
Product Name: Lamotrigine
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Purity: 99.0%
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lamotrigine

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