ZK93423

Modify Date: 2025-08-25 19:15:45

ZK93423 Structure
ZK93423 structure
Common Name ZK93423
CAS Number 83910-44-5 Molecular Weight 390.43200
Density 1.269g/cm3 Boiling Point 619.1ºC at 760 mmHg
Molecular Formula C23H22N2O4 Melting Point N/A
MSDS N/A Flash Point 328.2ºC

 Use of ZK93423


ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents[1].

 Names

Name 3-carboethoxy-6-benzyloxy-4-methoxymethyl-β-carboline

 ZK93423 Biological Activity

Description ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents[1].
Related Catalog
In Vivo ZK 93423(0.3-3 mg/kg,i.p.)在 B6C3F 1 品系的雄性小鼠中以 3mg/kg 的剂量引起体温过低[1]。
References

[1]. A H Tang, et al. Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice. Eur J Pharmacol. 1993 May 12;236(1):1-5  

 Chemical & Physical Properties

Density 1.269g/cm3
Boiling Point 619.1ºC at 760 mmHg
Molecular Formula C23H22N2O4
Molecular Weight 390.43200
Flash Point 328.2ºC
Exact Mass 390.15800
PSA 73.44000
LogP 4.61820
Index of Refraction 1.658
InChIKey ALBKMJDFBZVHAK-UHFFFAOYSA-N
SMILES CCOC(=O)c1ncc2[nH]c3ccc(OCc4ccccc4)cc3c2c1COC

 Safety Information

HS Code 2933990090

 Synthetic Route

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ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P. Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307

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ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P. Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307

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ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552

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ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P. Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307

~%

ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552

~%

ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552

~%

ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P. Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307

~%

ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Zhang, Haiming; Larock, Richard C. Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9318 - 9330

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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