GYKI-23107

Modify Date: 2023-10-21 20:15:55

GYKI-23107 Structure
GYKI-23107 structure
Common Name GYKI-23107
CAS Number 83843-39-4 Molecular Weight 279.24900
Density N/A Boiling Point 312.5ºC at 760 mmHg
Molecular Formula C13H24Cl2N2 Melting Point N/A
MSDS N/A Flash Point 117.5ºC

 Use of GYKI-23107


GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity. GYKI-23107 was effective against chemically (aconitine and ouabain) induced arrhythmias after both parenteral and oral administration. GYKI-23107 and mexiletine produced similar elevation of the fibrillation threshold in anaesthetized cats. After oral pretreatment, GYKI-23107 showed protective effects against coronary ligation-induced arrhythmia in conscious rats. The circulatory side-effects of GYKI-23107 in anaesthetized and conscious dogs and cats were milder then those of mexiletine.

 Names

Name 1-N-(2,6-dimethylphenyl)-2-N,2-N-dimethylpropane-1,2-diamine,dihydrochloride

 Chemical & Physical Properties

Boiling Point 312.5ºC at 760 mmHg
Molecular Formula C13H24Cl2N2
Molecular Weight 279.24900
Flash Point 117.5ºC
Exact Mass 278.13200
PSA 15.27000
LogP 4.34240

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TX8032260
CHEMICAL NAME :
1,2-Propanediamine, N(sup 2),N(sup 2)-dimethyl-N(sup 1)-2,6-xylyl-, dihydrochloride
CAS REGISTRY NUMBER :
83843-39-4
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C13-H22-N2.2Cl-H
MOLECULAR WEIGHT :
279.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
390 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
114 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987