TRV056
Modify Date: 2025-08-27 10:58:31
TRV056 structure
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Common Name | TRV056 | ||
|---|---|---|---|---|
| CAS Number | 812644-79-4 | Molecular Weight | 1103.23 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C52H74N14O13 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TRV056TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1]. |
| Name | TRV056 |
|---|
| Description | TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1]. |
|---|---|
| Related Catalog | |
| In Vitro | TRV056 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling[1]. |
| References |
| Molecular Formula | C52H74N14O13 |
|---|---|
| Molecular Weight | 1103.23 |
| InChIKey | NOMIXRQBVMELPF-IWIOKYJLSA-N |
| SMILES | CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)CNC(=O)C(CCCN=C(N)N)NC(=O)C(N)CC(=O)O)C(C)C)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O |