812644-79-4
812644-79-4 structure
- Name: TRV056
- Chemical Name: TRV056
- CAS Number: 812644-79-4
- Molecular Formula: C52H74N14O13
- Molecular Weight: 1103.23
- Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
- Create Date: 2021-07-28 10:35:37
- Modify Date: 2025-08-27 10:58:31
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TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1].
| Name | TRV056 |
|---|
| Description | TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1]. |
|---|---|
| Related Catalog | |
| In Vitro | TRV056 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling[1]. |
| References |
| Molecular Formula | C52H74N14O13 |
|---|---|
| Molecular Weight | 1103.23 |