TRV056

Names

[ Name ]:
TRV056

Biological Activity

[Description]:

TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor

[In Vitro]

TRV056 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling[1].

[References]

[1]. Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₂H₇₄N₁₄O₁₃

[ Molecular Weight ]:
1103.23

Related Compounds

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