9-Carboxymethoxymethylguanine

Modify Date: 2024-01-10 11:45:25

9-Carboxymethoxymethylguanine Structure
9-Carboxymethoxymethylguanine structure
Common Name 9-Carboxymethoxymethylguanine
CAS Number 80685-22-9 Molecular Weight 239.19
Density 1.9±0.1 g/cm3 Boiling Point 696.5±63.0 °C at 760 mmHg
Molecular Formula C8H9N5O4 Melting Point N/A
MSDS N/A Flash Point 375.0±33.7 °C

 Use of 9-Carboxymethoxymethylguanine


9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent[1].

 Names

Name 9-Carboxymethoxymethylguanine
Synonym More Synonyms

 9-Carboxymethoxymethylguanine Biological Activity

Description 9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent[1].
Related Catalog
In Vitro Acyclovir is metabolized by the alcohol dehydrogenase (ADH) enzyme to Acyclovir aldehyde, and acyclovir aldehyde is subsequently metabolized by the aldehyde dehydrogenase (ALDH) enzyme to 9-Carboxymethoxymethylguanine (CMMG)[1].
References

[1]. Patrina Gunness, et al. Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite. Transl Res. 2011 Nov;158(5):290-301.

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Boiling Point 696.5±63.0 °C at 760 mmHg
Molecular Formula C8H9N5O4
Molecular Weight 239.19
Flash Point 375.0±33.7 °C
Exact Mass 239.065460
LogP -1.37
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.802

 Synonyms

Acetic acid, 2-[(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-
N28227W35C
[(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]acetic acid
CMMG
9-Carboxymethoxymethylguanine