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9-Carboxymethoxymethylguanine

Names

[ CAS No. ]:
80685-22-9

[ Name ]:
9-Carboxymethoxymethylguanine

[Synonym ]:
Acetic acid, 2-[(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-
N28227W35C
[(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]acetic acid
CMMG
9-Carboxymethoxymethylguanine

Biological Activity

[Description]:

9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HSV
Research Areas >> Infection

[In Vitro]

Acyclovir is metabolized by the alcohol dehydrogenase (ADH) enzyme to Acyclovir aldehyde, and acyclovir aldehyde is subsequently metabolized by the aldehyde dehydrogenase (ALDH) enzyme to 9-Carboxymethoxymethylguanine (CMMG)[1].

[References]

[1]. Patrina Gunness, et al. Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite. Transl Res. 2011 Nov;158(5):290-301.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
696.5±63.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H9N5O4

[ Molecular Weight ]:
239.19

[ Flash Point ]:
375.0±33.7 °C

[ Exact Mass ]:
239.065460

[ LogP ]:
-1.37

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.802

Related Compounds