Prasterone
Modify Date: 2024-01-13 19:58:51
Prasterone structure
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Common Name | Prasterone | ||
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| CAS Number | 78590-17-7 | Molecular Weight | 426.50000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H31NaO7S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of PrasteronePrasterone is an endogenous steroid hormone that acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activities, including enhancing working memory and cognition, inhibiting proliferation and migration of cervical cancer cells, increasing expression of various glutamate transporters to suppress seizures, and minimizing gastric acid secretion, lipid peroxidation and ulcer formation. |
| Name | sodium,[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] sulfate,dihydrate |
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| Synonym | More Synonyms |
| Molecular Formula | C19H31NaO7S |
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| Molecular Weight | 426.50000 |
| Exact Mass | 426.16900 |
| PSA | 110.34000 |
| LogP | 4.31590 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Inhibition of the GABAA Receptor by Sulfated Neurosteroids: A Mechanistic Comparison Study between Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate.
J. Mol. Neurosci. 56(4) , 868-77, (2015) The γ-aminobutyric acid type A receptor (GABAAR) is negatively modulated by two structurally similar neurosteroids, pregnenolone sulfate (PS) and dehydroepiandrosterone sulfate (DHEAS). This study att... |
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Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors.
Stroke 31 , 1953-1957, (2000) Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) may function as neurotrophic or neuroprotective factors to protect central nervous system (CNS) neurons against a variety of insults, including e... |
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Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate.
J. Med. Chem. 41 , 2604-2613, (1998) The unnatural enantiomers of dehydroepiandrosterone sulfate (1), pregnenolone sulfate (2), and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate (3), compounds 4-6, respectively, were prepared by total s... |
| UNII-E1CR8487EN |
| Sodium dehydroepiandrosterone sulfate |
| E1CR8487EN |
| Prasterone sulfate sodium salt dihydrate |
| Mylis (TN) |