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855474-84-9 853-23-6

853-23-6

853-23-6 structure
853-23-6 structure
  • Name: Dehydroepiandrosterone acetate
  • Chemical Name: Dehydroisoandrosterone 3-acetate
  • CAS Number: 853-23-6
  • Molecular Formula: C21H30O3
  • Molecular Weight: 330.461
  • Catalog: analytical chemistry Standard Analytical standard
  • Create Date: 2018-04-19 08:00:00
  • Modify Date: 2024-01-02 21:36:19
  • Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.
Name Dehydroisoandrosterone 3-acetate
Synonyms EINECS 212-714-1
3β-acetoxyandrost-5-en-17-one
Dehydroepiandrosterone acetate
MFCD00021119
Epiandrosterone Acetate
(3β)-17-Oxoandrost-5-en-3-ylacetat
Androst-5-en-17-one, 3-(acetyloxy)-, (3β)-
DHEA-acetate, Dehydroepiandrosterone acetate
DHEA ACETATE
DEHYDRO EPIANDROSTERONE ACETATE
(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
3-Β-Hydroxy-Deoxyandrost-5-Ene-17-One-3-Acetate
DEHYDROANDROSTERONE ACETATE
DEHYDROEPIANDROSTERONE-3-ACETATE
DEHYDROISOANDROSTERONE ACETATE
DHEAacetate(prasterone acetate)
DEHYDROISOANDROSTERONE-3-ACETATE
ANDROST-5-EN-17-ONE, 3-(ACETYLOXY)-, (3SS)-
DEHYDROEPIANDROSTERONEACETATE(DHEAACETATE)
Dehydroepiandrosteroneacetate
DEHYDRO EPIANDROSTERONE 3-ACETATE
3-SS-HYDROXY-DEOXYANDROST-5-ENE-17-ONE-3-ACETATE
prasterone acetate
DEHYDRO EPIANDROSTERONE 3-ACETATE,OFF-WHITE SOLID
DHEAacetate
3-(ACETYLOXY)ANDROST-5-ENE-17-ONE
DEHYDROEPIANDROSTERONE ACETATE(DHA)
(3β)-17-Oxoandrost-5-en-3-yl acetate
Description Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.
Related Catalog
In Vivo Dehydroisoandrosterone implants increases aggression in a laboratory-based simulated territorial intrusion. Brains of Dehydroisoandrosterone-implanted birds show higher aromatase mRNA expression in the preoptic area (POA) and higher androgen receptor mRNA expression in the periventricular nucleus of the medial striatum (pvMSt) and ventromedial nucleus of the hypothalamus (VMH). The Dehydroisoandrosterone-induced increases in aromatase expression in the POA and androgen receptor expression in the pvMSt are consistent with previously reported seasonal increases in these markers associated with naturally elevated Dehydroisoandrosterone levels[1]. Dehydroisoandrosterone supplementation (10.2 mg/kg) alone significantly increases mice body weight (BW), muscle weight, testosterone level, and glycogen contents (liver and muscle) when compared with SC group[2].
Animal Admin The oral gavage treated with Dehydroisoandrosterone once a day for 6-week at 10.2 mg/day. SC group receives the same volume of distilled water equivalent to body weight. The Dehydroisoandrosterone supplementation in WBV+Dehydroisoandrosterone group is complete WBV training after 30 min. The recommended use of Dehydroisoandrosterone for humans is about 50 mg per one intake with a normal diet and exercise program. The mouse Dehydroisoandrosterone dose (10.2 mg/kg) used in this study is converted from a human equivalent dose on the basis of body surface area by the following formula from the US Food and Drug Administration 16: assuming a human weight of 60 kg, the human equivalent dose of 50 mg/60 kg (0.83 mg/kg)=0.83 × 12.3=a mouse dose of 10.2 mg/kg; the conversion coefficient 12.3 is used to account for differences in body surface area between a mouse and a human.
References

[1]. Wacker DW, et al. Dehydroepiandrosterone (DHEA) heightens aggression and increases androgen receptor and aromatase mRNA expression in the brain of a male songbird. J Neuroendocrinol. 2016 Nov 2.

[2]. Chen WC, et al. Dehydroepiandrosterone Supplementation Combined with Whole-Body Vibration Training Affects Testosterone Level and Body Composition in Mice. Int J Med Sci. 2016 Sep 16;13(10):730-740.
Density 1.1±0.1 g/cm3
Boiling Point 434.8±45.0 °C at 760 mmHg
Melting Point 168-170ºC
Molecular Formula C21H30O3
Molecular Weight 330.461
Flash Point 188.1±28.8 °C
Exact Mass 330.219482
PSA 43.37000
LogP 4.28
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.541
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BV8396810
CHEMICAL NAME :
Androst-5-en-17-one, 3-beta-hydroxy-, acetate
CAS REGISTRY NUMBER :
853-23-6
LAST UPDATED :
199706
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H30-O3
MOLECULAR WEIGHT :
330.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12600 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 83,1179,1992
Hazard Codes Xi
Safety Phrases 22-24/25
WGK Germany 3
RTECS BV8396810
HS Code 2937290090
HS Code 2937290090

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title: CAS No. 853-23-6 | Chemsrc address: https://www.chemsrc.com/en/baike/249361.html

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