Isoscopoletin

Modify Date: 2024-01-02 23:10:35

Isoscopoletin structure	Common Name	Isoscopoletin
	CAS Number	776-86-3	Molecular Weight	192.168
	Density	1.4±0.1 g/cm3	Boiling Point	413.5±45.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₈O₄	Melting Point	206-208ºC
	MSDS	N/A	Flash Point	172.4±22.2 °C

Use of Isoscopoletin

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].

Name	6-Hydroxy-7-methoxy-2H-chromen-2-one
Synonym	More Synonyms

Description	Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
References	[1]. Adams M, et al. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4. [2]. Li H, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71(12):1128-33.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

References

[1]. Adams M, et al. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4.

[2]. Li H, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71(12):1128-33.

Density	1.4±0.1 g/cm3
Boiling Point	413.5±45.0 °C at 760 mmHg
Melting Point	206-208ºC
Molecular Formula	C₁₀H₈O₄
Molecular Weight	192.168
Flash Point	172.4±22.2 °C
Exact Mass	192.042252
PSA	59.67000
LogP	0.83
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.609
Storage condition	2-8°C
Water Solubility	DMSO: soluble

Hazard Codes	Xi
Risk Phrases	R22
Safety Phrases	S22-24/25-36-26
WGK Germany	3
HS Code	29322090

2H-1-Benzopyran-2-one, 6-hydroxy-7-methoxy-

7-Methoxyesculetin

iso-Scopoletin

6-Hydroxy-7-methoxy-2H-chromen-2-one

6-hydroxy-7-methoxychromen-2-one

Isoscopoletin

EINECS 212-282-4

BioBioPha
China
Product Name: Isoscopoletin
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Isoscopoletin
Price: ￥788.0/10mg ￥1438.0/10mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Isoscopoletin
Price: $550.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-hydroxy-7-methoxy-2-benzopyrone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 6-HYDROXY-7-METHOXYCOUMARIN
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Isoscopoletin

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