Isoscopoletin

Modify Date: 2025-08-25 00:54:51

Isoscopoletin Structure
Isoscopoletin structure
 Common Name Isoscopoletin
CAS Number 776-86-3 Molecular Weight 192.168
Density 1.4±0.1 g/cm3 Boiling Point 413.5±45.0 °C at 760 mmHg
Molecular Formula C10H8O4 Melting Point 206-208ºC
MSDS N/A Flash Point 172.4±22.2 °C

 Use of Isoscopoletin


Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].

 Names

Name 6-Hydroxy-7-methoxy-2H-chromen-2-one
Synonym More Synonyms

 Isoscopoletin Biological Activity

Description Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].
Related Catalog
References

[1]. Adams M, et al. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4.

[2]. Li H, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71(12):1128-33.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 413.5±45.0 °C at 760 mmHg
Melting Point 206-208ºC
Molecular Formula C10H8O4
Molecular Weight 192.168
Flash Point 172.4±22.2 °C
Exact Mass 192.042252
PSA 59.67000
LogP 0.83
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.609
Storage condition 2-8°C
Water Solubility DMSO: soluble

 Safety Information

Hazard Codes Xi
Risk Phrases R22
Safety Phrases S22-24/25-36-26
WGK Germany 3
HS Code 29322090

 Synonyms

2H-1-Benzopyran-2-one, 6-hydroxy-7-methoxy-
7-Methoxyesculetin
iso-Scopoletin
6-Hydroxy-7-methoxy-2H-chromen-2-one
6-hydroxy-7-methoxychromen-2-one
Isoscopoletin
EINECS 212-282-4
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Chemsrc provides Isoscopoletin(CAS#:776-86-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Isoscopoletin are included as well.>> amp version: Isoscopoletin

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