776-86-3

776-86-3 structure

Name: Isoscopoletin
Chemical Name: 6-Hydroxy-7-methoxy-2H-chromen-2-one
CAS Number: 776-86-3
Molecular Formula: C₁₀H₈O₄
Molecular Weight: 192.168
Catalog: API Respiratory medication Asthma
Create Date: 2018-09-28 20:07:27
Modify Date: 2025-08-25 00:54:51
Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].

Name	6-Hydroxy-7-methoxy-2H-chromen-2-one
Synonyms	2H-1-Benzopyran-2-one, 6-hydroxy-7-methoxy- 7-Methoxyesculetin iso-Scopoletin 6-Hydroxy-7-methoxy-2H-chromen-2-one 6-hydroxy-7-methoxychromen-2-one Isoscopoletin EINECS 212-282-4

Description	Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
References	[1]. Adams M, et al. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4. [2]. Li H, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71(12):1128-33.