5-(2-bromovinyl)-2'-deoxyuridine-5'-triphosphate

Modify Date: 2024-04-03 17:02:26

5-(2-bromovinyl)-2'-deoxyuridine-5'-triphosphate Structure
5-(2-bromovinyl)-2'-deoxyuridine-5'-triphosphate structure
Common Name 5-(2-bromovinyl)-2'-deoxyuridine-5'-triphosphate
CAS Number 77222-61-8 Molecular Weight 573.08
Density N/A Boiling Point N/A
Molecular Formula C11H16BrN2O14P3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-(2-bromovinyl)-2'-deoxyuridine-5'-triphosphate


BVDU 5′-Triphosphate is an antivirus agent with 5′-Triphosphate label, targeting viral DNA polymerase. BVDU 5′-Triphosphate shows excellent selectivity against varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1), due to a specific phosphorylation by the virus-encoded thymidine kinase.

 Names

Name [[(2R,3S,5R)-5-[5-[(E)-2-bromoethenyl]-2,4-dioxopyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Synonym More Synonyms

  Biological Activity

Description BVDU 5′-Triphosphate is an antivirus agent with 5′-Triphosphate label, targeting viral DNA polymerase. BVDU 5′-Triphosphate shows excellent selectivity against varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1), due to a specific phosphorylation by the virus-encoded thymidine kinase.
Related Catalog
References

[1]. De Clercq E. Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster. Biochem Pharmacol. 2004 Dec 15;68(12):2301-15.  

 Chemical & Physical Properties

Molecular Formula C11H16BrN2O14P3
Molecular Weight 573.08
Exact Mass 571.90000
PSA 273.83000
LogP 0.30620

 Synonyms

BVdUTP
E-5-Bromovinyl-2'-deoxyuridine triphosphate