Brivudine

Modify Date: 2024-01-02 13:08:34

Brivudine structure	Common Name	Brivudine
	CAS Number	69304-47-8	Molecular Weight	333.135
	Density	1.9±0.1 g/cm3	Boiling Point	382.9ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₃BrN₂O₅	Melting Point	165ºC
	MSDS	USA	Flash Point	185.4ºC

Use of Brivudine

Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.

Name	Brivudine
Synonym	More Synonyms

Description	Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.
Related Catalog	Signaling Pathways >> Anti-infection >> CMV Research Areas >> Infection
In Vitro	Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2].
In Vivo	At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia[1].
References	[1]. Rabasseda X, et al. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71. [2]. Keam SJ, et al. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9.

Density	1.9±0.1 g/cm3
Boiling Point	382.9ºC at 760 mmHg
Melting Point	165ºC
Molecular Formula	C₁₁H₁₃BrN₂O₅
Molecular Weight	333.135
Flash Point	185.4ºC
Exact Mass	332.000763
PSA	104.55000
LogP	-0.80
Index of Refraction	1.709
Water Solubility	Soluble in water and methanol.

Brivudine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7355000

CHEMICAL NAME :: Uridine, 5-(2-bromovinyl)-2'-deoxy-, (E)-

CAS REGISTRY NUMBER :: 69304-47-8

LAST UPDATED :: 199509

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H13-Br-N2-O5

MOLECULAR WEIGHT :: 333.17

WISWESSER LINE NOTATION :: T6NVMVJ E1U1E A- ET5OTJ B1Q CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10920 mg/kg/52W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver - other changes Nutritional and Gross Metabolic - changes in chlorine

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 4 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 267,125,1992

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YU7355000

Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.

Biochem. J. 445(1) , 113-23, (2012)

In the present paper we demonstrate that the cytostatic and antiviral activity of pyrimidine nucleoside analogues is markedly decreased by a Mycoplasma hyorhinis infection and show that the phosphorol...

Synthesis of nucleoside-based antiviral drugs in ionic liquids.

Bioorg. Med. Chem. Lett. 18(20) , 5640-2, (2008)

Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of ...

Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts.

Nucleosides Nucleotides Nucleic Acids 29(1) , 1-13, (2010)

Thymidine kinase 2 (TK2) is a mitochondrial deoxyribonucleoside kinase that phosphorylates several nucleoside analogs used in anti-viral and anti-cancer therapy. A fibroblast cell line with decreased ...

5-[(E)-2-bromoethenyl]-2'-deoxyuridine

Brivudine

BrVDU

Bromovinyldeoxyuridine

MFCD00058585

5-[(E)-2-Bromovinyl]-2'-deoxyuridine

Zostrex

BVDU

Uridine, 5-[(E)-2-bromoethenyl]-2'-deoxy-

(E)-5-(2-Bromovinyl)-2'-deoxyuridine

BVDR

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Brivudine
Price: ￥1888.0/250mg ￥538.0/50mg ￥6638.0/1g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Brivudine
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Brivudine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Brivudine

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