LU-32-176B
Modify Date: 2025-09-17 18:04:30
LU-32-176B structure
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Common Name | LU-32-176B | ||
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| CAS Number | 770688-66-9 | Molecular Weight | 398.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H24F2N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LU-32-176BLU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2]. |
| Name | LU-32-176B |
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| Description | LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2]. |
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| Related Catalog | |
| Target |
LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2]. |
| In Vivo | LU-32-176B (i.p.) and EF1502 can prevent sound-induced seizures in the Frings AGS-susceptible mouse model[1]. |
| References |
| Molecular Formula | C23H24F2N2O2 |
|---|---|
| Molecular Weight | 398.45 |
| InChIKey | QOSIKKDOOCQXMT-UHFFFAOYSA-N |
| SMILES | O=c1[nH]oc2c1C(NCCCC(c1ccc(F)cc1)c1ccc(F)cc1)CCC2 |
| Hazard Codes | Xi |
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