(+)-Cedrol

Modify Date: 2025-08-21 18:56:29

(+)-Cedrol Structure
(+)-Cedrol structure
 Common Name (+)-Cedrol
CAS Number 77-53-2 Molecular Weight 222.366
Density 1.0±0.1 g/cm3 Boiling Point 277.2±8.0 °C at 760 mmHg
Molecular Formula C15H26O Melting Point 55-59 °C(lit.)
MSDS Chinese USA Flash Point 115.5±10.9 °C

 Use of (+)-Cedrol


Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes[1]. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, sedative, insecticidal, and anti-fungal activities[2].

 Names

Name cedrol
Synonym More Synonyms

 (+)-Cedrol Biological Activity

Description Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes[1]. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, sedative, insecticidal, and anti-fungal activities[2].
Related Catalog
Target

CYP2B6; CYP3A4; CYP2C8; CYP2C9; CYP2C19[1]

References

[1]. Jeong HU, et al. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77(22-24):1522-32.

[2]. Jin MH, et al. Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner. Ann Dermatol. 2012 Feb;24(1):16-21

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 277.2±8.0 °C at 760 mmHg
Melting Point 55-59 °C(lit.)
Molecular Formula C15H26O
Molecular Weight 222.366
Flash Point 115.5±10.9 °C
Exact Mass 222.198364
PSA 20.23000
LogP 4.77
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.519

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS PB7728666
HS Code 2906199090

 Customs

HS Code 2906299090
Summary 2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles21

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Fragrance material review on cedrol.

Food Chem. Toxicol. 46 Suppl 11 , S100-2, (2008)

A toxicologic and dermatologic review of cedrol when used as a fragrance ingredient is presented.

 Synonyms

8bH-Cedran-8-ol
EINECS 201-035-6
Cedarwood oil alcohols
(8α)-Cedran-8-ol
Cedar camphor
(1S,2R,5S,7R,8R)-2,6,6,8-Tetramethyltricyclo[5.3.1.0]undecan-8-ol
8betaH-Cedran-8-ol
EUDESMOL
1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-, (3R,3aS,6R,7R,8aS)-
(1S,2R,5S,7R,8R)-2,6,6,8-Tétraméthyltricyclo[5.3.1.0]undécan-8-ol
Cypress camphor
8βH-cedran-8-ol
[3R-(3a,3ab,6a,7b,8aa)]-Octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol
Cedrol
MFCD00062952
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