7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin

Modify Date: 2025-08-25 15:06:53

7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin Structure
7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin structure
Common Name 7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin
CAS Number 76877-34-4 Molecular Weight 490.33400
Density 1.531g/cm3 Boiling Point 658.2ºC at 760 mmHg
Molecular Formula C22H23IN2O3 Melting Point N/A
MSDS USA Flash Point 351.9ºC
Symbol GHS06
GHS06
Signal Word Danger

 Use of 7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin


DCIA is a fluorescent dye. DCIA contains a coumarin fluorophore and conjugates specifically with free cysteines in the protein[1].

 Names

Name N-[4-[7-(diethylamino)-4-methyl-2-oxochromen-3-yl]phenyl]-2-iodoacetamide
Synonym More Synonyms

  Biological Activity

Description DCIA is a fluorescent dye. DCIA contains a coumarin fluorophore and conjugates specifically with free cysteines in the protein[1].
Related Catalog
References

[1]. Branigan E, et al. Quantification of free cysteines in membrane and soluble proteins using a fluorescent dye and thermal unfolding. Nat Protoc. 2013 Nov;8(11):2090-7.

 Chemical & Physical Properties

Density 1.531g/cm3
Boiling Point 658.2ºC at 760 mmHg
Molecular Formula C22H23IN2O3
Molecular Weight 490.33400
Flash Point 351.9ºC
Exact Mass 490.07500
PSA 62.55000
LogP 5.06110
Index of Refraction 1.67
InChIKey WIXAQXKQLNRFDF-UHFFFAOYSA-N
SMILES CCN(CC)c1ccc2c(C)c(-c3ccc(NC(=O)CI)cc3)c(=O)oc2c1

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H413
Precautionary Statements P301 + P310
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
RIDADR UN 2811 6.1 / PGIII
HS Code 2932209090

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles4

More Articles
High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.

J. Chromatogr. A. 530(1) , 57-64, (1990)

7-(Diethylamino)-3-[4-[iodoacetyl)amino)phenyl]-4-methylcoumarin (DCIA) and 4-(bromomethyl)-7-methoxycoumarin have been evaluated as fluoropyrimidine-derivatizing agents to be detected using peroxyoxa...

Fluorescence characterization of the environment encountered by nascent polyalanine and polyserine as they exit Escherichia coli ribosomes during translation.

Biochemistry 31(8) , 2368-75, (1992)

The fate of the amino termini of nascent polyalanine, polyserine, and polylysine was monitored by fluorescence techniques as each was translated on Escherichia coli ribosomes. A coumarin probe was pla...

New fluorochromes for thiols: maleimide and iodoacetamide derivatives of a 3-phenylcoumarin fluorophore.

J. Histochem. Cytochem. 29(2) , 314-6, (1981)

N-(4-(7 - Diethylamino - methylcoumarin - 3 yl)phenyl)maleimide (CPM) and the corresponding iodoacetamide are described. When applied to sections at pH 6 and 9, respectively, the two fluorogens are ve...

 Synonyms

n-{4-[7-(diethylamino)-4-methyl-2-oxo-2h-chromen-3-yl]phenyl}-2-iodoacetamide
Demcpi
7-DIETHYLAMINO-3-[4-(IODOACETAMIDO)PHENYL]-4-METHYLCOUMARIN
DCIA
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