8-Hydroxy-DPAT hydrobromide

Modify Date: 2025-08-25 11:13:46

8-Hydroxy-DPAT hydrobromide Structure
8-Hydroxy-DPAT hydrobromide structure
Common Name 8-Hydroxy-DPAT hydrobromide
CAS Number 76135-31-4 Molecular Weight 328.28800
Density N/A Boiling Point N/A
Molecular Formula C16H26BrNO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 8-Hydroxy-DPAT hydrobromide


8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1].

 Names

Name 8-Hydroxy-DPAT hydrobromide,(±)-7-Hydroxy-2-dipropylaminotetralinhydrobromide
Synonym More Synonyms

 8-Hydroxy-DPAT hydrobromide Biological Activity

Description 8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1].
Related Catalog
Target

5-HT1A Receptor:8.19 (pIC50)

In Vitro 8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) has no effect on 5-HT1B binding at concentrations lower than 100 nM[1].
In Vivo 8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide; 32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals[1].
References

[1]. D N Middlemiss, et al. 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site. Eur J Pharmacol. 1983 May 20;90(1):151-3.

[2]. Michael A Taffe, et al. Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge. Neuropsychopharmacology. 2002 Dec;27(6):993-1005.

 Chemical & Physical Properties

Molecular Formula C16H26BrNO
Molecular Weight 328.28800
Exact Mass 327.12000
PSA 23.47000
LogP 4.32960
Storage condition 2-8°C

 Safety Information

HS Code 2922299090

 Customs

HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

8-OH-DPAT HRr
rac-8-Hydroxy-2-dipropylaMinotetralin HydrobroMide
Serotonin agonist DPAT
8-OH-DPAT hydrobromide
8-hydroxydipropyl-aminotetralin
8-OH-DPAT HBr
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