(Rac)-WAY-161503

Modify Date: 2024-01-02 19:42:02

(Rac)-WAY-161503 structure	Common Name	(Rac)-WAY-161503
	CAS Number	75704-24-4	Molecular Weight	308.59100
	Density	N/A	Boiling Point	529ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₁Cl₂N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	273.7ºC

Use of (Rac)-WAY-161503

(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects[1][2].

Name	8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one

Description	(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects[1][2].
Related Catalog	Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT2C Receptor:4 nM (Ki) 5-HT2C Receptor:12 nM (EC50)
In Vivo	(Rac)-WAY-161503 (3-30 mg/kg; intraperitoneal injection; male C57BL/6J mice) treatment dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT2C/2B antagonist SER-082. Additionally, the decreased locomotor activity produced by 10 mg/kg DOI is potentiated in the 5-HT2A KO mice[1]. Animal Model: Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)[1] Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg Administration: Intraperitoneal injection Result: Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT2C/2B antagonist SER-082.
References	[1]. Halberstadt AL, et al. 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology. 2009 Jul;34(8):1958-67. [2]. Welmaker GS, et al. Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1991-4.

Boiling Point	529ºC at 760 mmHg
Molecular Formula	C₁₁H₁₁Cl₂N₃O
Molecular Weight	308.59100
Flash Point	273.7ºC
Exact Mass	307.00500
PSA	44.37000
LogP	3.05750

3-Carbobenzylox...

CAS#:276695-08-0

(Rac)-WAY-161503

CAS#:75704-24-4

Literature: Welmaker, Gregory S.; Nelson, James A.; Sabalski, Joan E.; Sabb, Annmarie L.; Potoski, John R.; Graziano, Denise; Kagan, Michael; Coupet, Joseph; Dunlop, John; Mazandarani, Hossein; Rosenzweig-Lipson, Sharon; Sukoff, Stacey; Zhang, Yingxin Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 1991 - 1994

N/A

CAS#:934630-06-5

(Rac)-WAY-161503

CAS#:75704-24-4

4-carbobenzylox...

CAS#:276695-07-9

(Rac)-WAY-161503

CAS#:75704-24-4

Precursor 2
CAS#:276695-08-0 3-Carbobenzylox... CAS#:276695-07-9 4-carbobenzylox...
DownStream 0

DC Chemicals Limited
China
Product Name: (Rac)-WAY-161503
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

(Rac)-WAY-161503 suppliers

Price: ￥3900/5 mg

Reference only. check more (Rac)-WAY-161503 price

(Rac)-WAY-161503

Use of (Rac)-WAY-161503

Names

(Rac)-WAY-161503 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream