CID 5951923
Modify Date: 2024-01-04 17:06:00
CID 5951923 structure
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Common Name | CID 5951923 | ||
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| CAS Number | 749872-43-3 | Molecular Weight | 382.38800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H18N2O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CID 5951923CID 5951923 is a potent inhibitor of Krüppel-like factor 5 (KLF5), with an IC50 of 603 nM. CID 5951923 can inhibit proliferation of cancer cells in vitro[1]. |
| Name | 2-[(1,1-Dioxidotetrahydro-3-thiophenyl)(methyl)amino]-2-oxoethyl (2E)-3-(3-nitrophenyl)acrylate |
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| Synonym | More Synonyms |
| Description | CID 5951923 is a potent inhibitor of Krüppel-like factor 5 (KLF5), with an IC50 of 603 nM. CID 5951923 can inhibit proliferation of cancer cells in vitro[1]. |
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| Related Catalog | |
| Target |
IC50: 603 nM (KLF5)[1] |
| In Vitro | CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner[1]. CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY1068, and downregulated EGR1[1]. CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells[1]. Cell Viability Assay[1] Cell Line: DLD-1 and IEC-6 cells Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM Incubation Time: 48 h Result: Inhibited proliferation of DLD-1 cells with an IC50 of 1.6 μM. |
| References |
| Molecular Formula | C16H18N2O7S |
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| Molecular Weight | 382.38800 |
| Exact Mass | 382.08300 |
| PSA | 134.95000 |
| LogP | 2.40070 |
| RIDADR | NONH for all modes of transport |
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| MFCD04796932 |