638156-11-3

638156-11-3 structure

Name: CID-2011756
Chemical Name: 5-(3-chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide
CAS Number: 638156-11-3
Molecular Formula: C₂₂H₂₁ClN₂O₃
Molecular Weight: 396.867
Catalog: Signaling Pathways Apoptosis PKD
Create Date: 2018-12-20 17:40:33
Modify Date: 2024-01-19 10:04:52
CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.

Name	5-(3-chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide
Synonyms	QCR-12 5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furamide HMS2426M13 2-Furancarboxamide, 5-(3-chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]- cc-693 CID-2011756 CID 2011756

Description	CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.
Related Catalog	Signaling Pathways >> Apoptosis >> PKD Research Areas >> Cancer
Target	Cellular PKD2:0.6 μM (IC50) Cellular PKD3:0.7 μM (IC50) PKD1:3.2 μM (IC50)
In Vitro	CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC50 of 3.2 µM. CID 2011756 decreases the phosphorylation of endogenous PKD1 Ser916 in LNCaP cancer cells with an EC50 of 10±0.7 µM. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC50s of 0.6±0.1 µM and 0.7±0.2 µM for PKD2 and PKD3, respectively[1].
References	[1]. Sharlow ER, et al. Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS One. 2011;6(10):e25134.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport