CID 5951923

CID 5951923 is a potent inhibitor of Krüppel-like factor 5 (KLF5), with an IC50 of 603 nM. CID 5951923 can inhibit proliferation of cancer cells in vitro[1].

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> KLF

IC50: 603 nM (KLF5)[1]

CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner[1]. CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY1068, and downregulated EGR1[1]. CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells[1]. Cell Viability Assay[1] Cell Line: DLD-1 and IEC-6 cells Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM Incubation Time: 48 h Result: Inhibited proliferation of DLD-1 cells with an IC50 of 1.6 μM.

[1]. Bialkowska AB, et, al. Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol Cancer Ther. 2011 Nov; 10(11): 2043-51.