JH-131e-153
Modify Date: 2025-07-26 13:58:03
JH-131e-153 structure
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Common Name | JH-131e-153 | ||
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| CAS Number | 742104-91-2 | Molecular Weight | 382.53 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H38O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JH-131e-153JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases[1]. |
| Name | JH-131e-153 |
|---|
| Description | JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases[1]. |
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| Related Catalog | |
| Target |
Munc13-1 C1 domain[1] |
| References |
[1]. Das J, et al. Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones. Biochemistry. 2023 Aug 31. |
| Molecular Formula | C22H38O5 |
|---|---|
| Molecular Weight | 382.53 |
| InChIKey | XKEOGEXDEKIDNA-JVGWPHRLSA-N |
| SMILES | CC(C)CC(CC=C1CC(CO)(COC(=O)C(C)(C)C)OC1=O)CC(C)C |