742104-91-2
742104-91-2 structure
- Name: JH-131e-153
- Chemical Name: JH-131e-153
- CAS Number: 742104-91-2
- Molecular Formula: C22H38O5
- Molecular Weight: 382.53
- Catalog: Research Areas Neurological Disease
- Create Date: 2025-03-10 13:01:07
- Modify Date: 2025-07-26 13:58:03
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JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases[1].
| Name | JH-131e-153 |
|---|
| Description | JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases[1]. |
|---|---|
| Related Catalog | |
| Target |
Munc13-1 C1 domain[1] |
| References |
[1]. Das J, et al. Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones. Biochemistry. 2023 Aug 31. |
| Molecular Formula | C22H38O5 |
|---|---|
| Molecular Weight | 382.53 |