Mosloflavone

Modify Date: 2024-01-02 20:31:48

Mosloflavone Structure
Mosloflavone structure
 Common Name Mosloflavone
CAS Number 740-33-0 Molecular Weight 298.290
Density 1.3±0.1 g/cm3 Boiling Point 508.5±50.0 °C at 760 mmHg
Molecular Formula C17H14O5 Melting Point 163-164ºC (chloroform , acetone )
MSDS N/A Flash Point 190.5±23.6 °C

 Use of Mosloflavone


Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with  anti-EV71 activity. Mosloflavone  inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

 Names

Name 5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one
Synonym More Synonyms

 Mosloflavone Biological Activity

Description Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with  anti-EV71 activity. Mosloflavone  inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.
Related Catalog
Target

IC50: EV71; bacterial[1][2]
In Vitro Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases[2].
References

[1]. 2.Choi HJ, et al. Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8.

[2]. 2.Hnamte S, et al. Mosloflavone attenuates the quorum sensing controlled virulence phenotypes and biofilm formation in Pseudomonas aeruginosa PAO1: In vitro, in vivo and in silico approach.Microb Pathog. 2019 Jun;131:128-134.

[3]. 4.Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 508.5±50.0 °C at 760 mmHg
Melting Point 163-164ºC (chloroform , acetone )
Molecular Formula C17H14O5
Molecular Weight 298.290
Flash Point 190.5±23.6 °C
Exact Mass 298.084137
PSA 68.90000
LogP 2.74
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.622

 Safety Information

HS Code 2914509090

 Synthetic Route

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

5-hydroxy-6,7-dimethoxy-2-phenylchromen-4-one
5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one
baicalein 6,7-dimethyl ether
4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-phenyl-
Mosloflavone
5-hydroxy-6,7-dimethoxyflavone
Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Mosloflavone
  • Price: ￥1000.0/5mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

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Price: ￥6015/1g

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Related Compounds: More...
Mosloflavone
66648-43-9
Chemsrc provides Mosloflavone(CAS#:740-33-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Mosloflavone are included as well.>> amp version: Mosloflavone

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