Mosloflavone

Names

[ CAS No. ]:
740-33-0

[ Name ]:
Mosloflavone

[Synonym ]:
5-hydroxy-6,7-dimethoxy-2-phenylchromen-4-one
5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one
baicalein 6,7-dimethyl ether
4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-phenyl-
Mosloflavone
5-hydroxy-6,7-dimethoxyflavone

Biological Activity

[Description]:

Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with anti-EV71 activity. Mosloflavone inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: EV71; bacterial[1][2]

[In Vitro]

Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases[2].

[References]

[1]. 2.Choi HJ, et al. Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8.

[2]. 2.Hnamte S, et al. Mosloflavone attenuates the quorum sensing controlled virulence phenotypes and biofilm formation in Pseudomonas aeruginosa PAO1: In vitro, in vivo and in silico approach.Microb Pathog. 2019 Jun;131:128-134.

[3]. 4.Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
508.5±50.0 °C at 760 mmHg

[ Melting Point ]:
163-164ºC (chloroform , acetone )

[ Molecular Formula ]:
C₁₇H₁₄O₅

[ Molecular Weight ]:
298.290

[ Flash Point ]:
190.5±23.6 °C

[ Exact Mass ]:
298.084137

[ PSA ]:
68.90000

[ LogP ]:
2.74

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.622

Safety Information

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Related Compounds

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