[D-Trp11]-Neurotensin

Modify Date: 2025-08-27 11:18:27

[D-Trp11]-Neurotensin structure	Common Name	[D-Trp11]-Neurotensin
	CAS Number	73634-68-1	Molecular Weight	1695.96
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₀H₁₂₂N₂₂O₁₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of [D-Trp11]-Neurotensin

[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension[1][2].

Name	PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH
Synonym	More Synonyms

Description	[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Neurological Disease
Target	Neurotensin Receptor[1]
In Vitro	[D-Trp11]-Neurotensin (0.13-1.1 μM) markedly inhibits NT-induced coronary vessel constriction in perfused rat hearts[1]. [D-Trp11]-Neurotensin (2-110 μM) exhibits NT-like activity in perfused rat hearts[1].
In Vivo	[D-Trp11]-Neurotensin (50-500 nmol/kg; i.v.) has hypotensive activity in pentobarbital-anesthetized rats, with an ED25 of 122 nmol/kg[2].
References	[1]. Quirion R, et, al. Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue. Eur J Pharmacol. 1980 Feb 8;61(3):309-12. [2]. Quirion R, et, al. Hypotensive effects of centrally and peripherally administered neurotensin and neurotensin derivatives in rats. Neuropeptides. 1981 Jou. 1(4): 253-9.

Molecular Formula	C₈₀H₁₂₂N₂₂O₁₉
Molecular Weight	1695.96
InChIKey	XHUBQRRWQWIRQR-HEIFKUMQSA-N
SMILES	CCC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C1CCCN1C(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CCC(=O)O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(C)C)NC(=O)C1CCC(=O)N1)C(=O)NC(CC(C)C)C(=O)O
Storage condition	-15°C

(D-TRP11)-NEUROTENSIN

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China
Product Name: PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH
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Purity: 98.0%
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