[D-Trp11]-Neurotensin

Names

[ Name ]:
[D-Trp11]-Neurotensin

[Synonym ]:
(D-TRP11)-NEUROTENSIN

Biological Activity

[Description]:

[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor

Research Areas >> Neurological Disease

[Target]

Neurotensin Receptor[1]

[In Vitro]

[D-Trp11]-Neurotensin (0.13-1.1 μM) markedly inhibits NT-induced coronary vessel constriction in perfused rat hearts[1]. [D-Trp11]-Neurotensin (2-110 μM) exhibits NT-like activity in perfused rat hearts[1].

[In Vivo]

[D-Trp11]-Neurotensin (50-500 nmol/kg; i.v.) has hypotensive activity in pentobarbital-anesthetized rats, with an ED25 of 122 nmol/kg[2].

[References]

[1]. Quirion R, et, al. Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue. Eur J Pharmacol. 1980 Feb 8;61(3):309-12.

[2]. Quirion R, et, al. Hypotensive effects of centrally and peripherally administered neurotensin and neurotensin derivatives in rats. Neuropeptides. 1981 Jou. 1(4): 253-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₀H₁₂₂N₂₂O₁₉

[ Molecular Weight ]:
1695.96

[ Storage condition ]:
-15°C

Related Compounds

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