Macbecin I

Modify Date: 2025-08-27 09:46:27

Macbecin I structure	Common Name	Macbecin I
	CAS Number	73341-72-7	Molecular Weight	558.66300
	Density	1.17g/cm3	Boiling Point	736.2ºC at 760 mmHg
	Molecular Formula	C₃₀H₄₂N₂O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	399ºC

Use of Macbecin I

Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities[1].

Name	Macbecin I,(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
Synonym	More Synonyms

Description	Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP90:2 μM (IC50) HSP90:0.24 μM (Kd)
References	[1]. Martin CJ, et al. Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem. 2008 May 8;51(9):2853-7.

Density	1.17g/cm3
Boiling Point	736.2ºC at 760 mmHg
Molecular Formula	C₃₀H₄₂N₂O₈
Molecular Weight	558.66300
Flash Point	399ºC
Exact Mass	558.29400
PSA	143.25000
LogP	4.36350
Index of Refraction	1.545
InChIKey	PLTGBUPHJAKFMA-FYJPNMAESA-N
SMILES	COC1CC(C)C(OC)C2=CC(=O)C=C(NC(=O)C(C)=CC=CC(C)C(OC(N)=O)C(C)=CC(C)C1OC)C2=O

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL9055000

CHEMICAL NAME :: Macbecin I

CAS REGISTRY NUMBER :: 73341-72-7

LAST UPDATED :: 198509

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C30-H42-N2-O8

MOLECULAR WEIGHT :: 558.74

WISWESSER LINE NOTATION :: T6-19- A AV DV GMV IU KU OU&TJ I1 M1 NOVZ O1 Q1 RO1 SO1 U1 VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,205,1980

macbecin I

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Macbecin I
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Macbecin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Geldanamycin,6,17-didemethoxy-15-methoxy-6-methyl-11-O-methyl-, (15R)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Macbecin I

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.