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Macbecin I

Names

[ CAS No. ]:
73341-72-7

[ Name ]:
Macbecin I

[Synonym ]:
macbecin I

Biological Activity

[Description]:

Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

HSP90:2 μM (IC50)

HSP90:0.24 μM (Kd)


[References]

[1]. Martin CJ, et al. Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem. 2008 May 8;51(9):2853-7.

Chemical & Physical Properties

[ Density]:
1.17g/cm3

[ Boiling Point ]:
736.2ºC at 760 mmHg

[ Molecular Formula ]:
C30H42N2O8

[ Molecular Weight ]:
558.66300

[ Flash Point ]:
399ºC

[ Exact Mass ]:
558.29400

[ PSA ]:
143.25000

[ LogP ]:
4.36350

[ Index of Refraction ]:
1.545

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OL9055000
CHEMICAL NAME :
Macbecin I
CAS REGISTRY NUMBER :
73341-72-7
LAST UPDATED :
198509
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C30-H42-N2-O8
MOLECULAR WEIGHT :
558.74
WISWESSER LINE NOTATION :
T6-19- A AV DV GMV IU KU OU&TJ I1 M1 NOVZ O1 Q1 RO1 SO1 U1 VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,205,1980

Related Compounds

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