Calcium 2-oxopentanedioate

Modify Date: 2024-01-02 22:49:07

Calcium 2-oxopentanedioate Structure
Calcium 2-oxopentanedioate structure
Common Name Calcium 2-oxopentanedioate
CAS Number 71686-01-6 Molecular Weight 184.160
Density N/A Boiling Point 345.6ºC at 760 mmHg
Molecular Formula C5H4CaO5 Melting Point N/A
MSDS N/A Flash Point 177ºC

 Use of Calcium 2-oxopentanedioate


2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid calcium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid calcium is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].

 Names

Name calcium,2-oxopentanedioate
Synonym More Synonyms

 Calcium 2-oxopentanedioate Biological Activity

Description 2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid calcium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid calcium is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].
Related Catalog
Target

Tyrosinase:15 mM (IC50)

Human Endogenous Metabolite

In Vitro 2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1]. 2-Ketoglutaric acid calcium acts as precursor for the synthesis of amino acids and nucleotides[2].
References

[1]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35.

[2]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.

 Chemical & Physical Properties

Boiling Point 345.6ºC at 760 mmHg
Molecular Formula C5H4CaO5
Molecular Weight 184.160
Flash Point 177ºC
Exact Mass 183.968460
PSA 69.67000

 Safety Information

HS Code 2918300090

 Customs

HS Code 2918300090
Summary 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

EINECS 275-843-2
Pentanedioic acid, 2-oxo-, calcium salt (1:1)
MFCD02683879
calcium 2-oxidanylidenepentanedioate
2-oxo-glutaric acid,calcium salt
2-Oxo-glutarsaeure,Calcium-Salz
Calcium 2-oxopentanedioate
Calcium 2-oxoglutarate