Calcium 2-oxopentanedioate

Names

[ Name ]:
Calcium 2-oxopentanedioate

[Synonym ]:
EINECS 275-843-2
Pentanedioic acid, 2-oxo-, calcium salt (1:1)
MFCD02683879
calcium 2-oxidanylidenepentanedioate
2-oxo-glutaric acid,calcium salt
2-Oxo-glutarsaeure,Calcium-Salz
Calcium 2-oxopentanedioate
Calcium 2-oxoglutarate

Biological Activity

[Description]:

2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid calcium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid calcium is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[Target]

Tyrosinase:15 mM (IC50)

Human Endogenous Metabolite

[In Vitro]

2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1]. 2-Ketoglutaric acid calcium acts as precursor for the synthesis of amino acids and nucleotides[2].

[References]

[1]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35.

[2]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.

Chemical & Physical Properties

[ Boiling Point ]:
345.6ºC at 760 mmHg

[ Molecular Formula ]:
C₅H₄CaO₅

[ Molecular Weight ]:
184.160

[ Flash Point ]:
177ºC

[ Exact Mass ]:
183.968460

[ PSA ]:
69.67000

Safety Information

[ HS Code ]:
2918300090

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%