(S)-Amisulpride

Modify Date: 2024-01-19 17:45:11

(S)-Amisulpride structure	Common Name	(S)-Amisulpride
	CAS Number	71675-92-8	Molecular Weight	369.48
	Density	1.2±0.1 g/cm3	Boiling Point	558.9±50.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₂₇N₃O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	291.8±30.1 °C

Use of (S)-Amisulpride

(S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a KI of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects[1][2].

Name	ES3TWM82E8
Synonym	More Synonyms

Description	(S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a KI of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	D2 Receptor D3 Receptor 5-HT7 Receptor:900 nM (Ki)
In Vitro	(S)-Amisulpride (Esamisulpride) displays high affinity binding at both D2 and D3 receptors and is approximately twice as potent as racamisulpride and 20–50 times more potent than (R)-amisulpride at these receptors[2]
In Vivo	The (S)-amisulpride (10mg/kg, s.c.) stimulus is rapidly acquired and was shown to be dose-related, time dependent (effective between 30 and 120min) and stereoselective male C57BL/6 mice[1].
References	[1]. Timothy J Donahue, et al. (S)-amisulpride as a discriminative stimulus in C57BL/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics. Eur J Pharmacol. 2014 Jul 5;734:15-22. [2]. Vincent Grattan, et al. Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D₂ and D₃, while R Enantiomers Engage 5-HT₇. ACS Omega. 2019 Aug 15;4(9):14151-14154.

Density	1.2±0.1 g/cm3
Boiling Point	558.9±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₇N₃O₄S
Molecular Weight	369.48
Flash Point	291.8±30.1 °C
Exact Mass	369.172241
LogP	1.60
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.546

4-Amino-N-{[(2S)-1-ethyl-2-pyrrolidinyl]methyl}-5-(ethylsulfonyl)-2-methoxybenzamide

EINECS 275-831-7

(S)-AMISULPRIDE

Benzamide, 4-amino-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-5-(ethylsulfonyl)-2-methoxy-

ES3TWM82E8

DC Chemicals Limited
China
Product Name: (S)-Amisulpride
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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