Vinorelbine

Modify Date: 2024-01-02 16:48:14

Vinorelbine structure	Common Name	Vinorelbine
	CAS Number	71486-22-1	Molecular Weight	778.932
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₄₅H₅₄N₄O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Vinorelbine

Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

Name	vinorelbine
Synonym	More Synonyms

Description	Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
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In Vitro	Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase[1]. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner[2].
In Vivo	After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs[3]. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2[4].
Animal Admin	As defined by the study, VRL1 is diluted in 0.9% NaCl to a concentration of 1.5 mg/mL, and given IV over 5 minutes. The intended treatment interval is 7 days for up to 4 treatments. After receiving 4 weekly doses, cats are eligible to continue VRL treatment every 2 weeks at the owner's expense.
References	[1]. Ngan VK, et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul;60(1):225-32. [2]. Liu XM, et al. Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells. Br J Cancer. 2003 Oct 20;89(8):1566-73. [3]. Poirier VJ, et al. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med. 2004 Jul-Aug;18(4):536-9. [4]. Pierro JA, et al. Phase I clinical trial of vinorelbine in tumor-bearing cats. J Vet Intern Med. 2013 Jul-Aug;27(4):943-8.

Density	1.4±0.1 g/cm3
Molecular Formula	C₄₅H₅₄N₄O₈
Molecular Weight	778.932
Exact Mass	778.394165
PSA	133.87000
LogP	4.69
Index of Refraction	1.676
Storage condition	2-8C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RD2530000

CHEMICAL NAME :: C'-Norvincaleukoblastine, 3',4'-didehydro-4'-deoxy-

CAS REGISTRY NUMBER :: 71486-22-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C45-H54-N4-O8

MOLECULAR WEIGHT :: 779.03

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTKRDX Gan to Kagaku Ryoho. Cancer and Chemotherapy. (1-8-9 Yaesu, Chuo-ku, Tokyo 103, Japan) V.1- 1974- Volume(issue)/page/year: 10,1050,1983

bromo-12 nor-5'...

CAS#:89384-09-8

~79%

Vinorelbine

CAS#:71486-22-1

Literature: Gueritte; Pouilhes; Mangeney; et al. European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 419 - 424

CAS#:89368-94-5

~77%

Vinorelbine

CAS#:71486-22-1

Literature: Gueritte; Pouilhes; Mangeney; et al. European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 419 - 424

CAS#:89368-94-5

~76%

bromo-12 nor-5'...

CAS#:89384-09-8

Vinorelbine

CAS#:71486-22-1

Literature: European Journal of Medicinal Chemistry, , vol. 18, # 5 p. 419 - 424

Vincaleukoblast...

CAS#:38390-45-3

Vinorelbine

CAS#:71486-22-1

Literature: European Journal of Medicinal Chemistry, , vol. 18, # 5 p. 419 - 424

Precursor 1
CAS#:38390-45-3 Vincaleukoblast...
DownStream 1
CAS#:162652-95-1 Vinflunine

Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-15-[(12S)-16-ethyl-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8,15-pentaen-12-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate

8-methylsulfanyl-5-nonylsulfanyl-quinoline

aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-

vinorebline

3',4'-didehydro-4'-desoxy-8'-norvincaleucoblastine

5-Nonylthio-8-methylthio-chinolin

5'-noranhydrovinblastine

vinorelbene

Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-15-[(12S)-16-ethyl-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8,15-pentaen-12-yl]-3-hydroxy-16-methox y-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate

Quinoline,8-(methylthio)-5-(nonylthio)

Vinorelbine

Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, meth ;yl ester, (2β,3β,4β,5α,12β,19α)-

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Vinorelbine
Price: ￥788.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Vinorelbine
Price: $600.0/100mg $1000.0/250mg $1950.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Vinorelbine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Vinorelbine

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