Suxamethonium chloride

MOLECULAR WEIGHT :

361.36

WISWESSER LINE NOTATION :

1K1&1&2OV2VO2K1&1&1 &Q 2 &G 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

1429 ug/kg

TOXIC EFFECTS :

Nutritional and Gross Metabolic - changes in potassium

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

7 mg/kg

TOXIC EFFECTS :

Nutritional and Gross Metabolic - changes in potassium Cardiac - arrhythmias (including changes in conduction)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1250 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

430 ug/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

240 ug/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Behavioral - rigidity (including catalepsy)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Bird - chicken

DOSE/DURATION :

300 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :

Rodent - mouse

DOSE/DURATION :

2500 ug/kg

REFERENCE :

MSCREJ Medical Science Research. (Elsevier Applied Science Pub. Ltd., Crown House, Linton Rd., Barking, Essex IG11 8JU, UK) V.15- 1987- Volume(issue)/page/year: 20,759,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84013 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 400 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84013 No. of Facilities: 207 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 10334 (estimated) No. of Female Employees: 9106 (estimated)