Ormetoprim

Modify Date: 2025-08-22 18:12:24

Ormetoprim Structure
Ormetoprim structure
 Common Name Ormetoprim
CAS Number 6981-18-6 Molecular Weight 274.318
Density 1.3±0.1 g/cm3 Boiling Point 398.2±52.0 °C at 760 mmHg
Molecular Formula C14H18N4O2 Melting Point 233°C
MSDS N/A Flash Point 194.6±30.7 °C

 Use of Ormetoprim


Ormetoprim is a veterinary antimicrobial which commonly used in aquaculture and poultry industries. Ormetoprim can be used to prevent the spread of disease in freshwater aquaculture and promote growth in farm animals[1][2].

 Names

Name 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine
Synonym More Synonyms

 Ormetoprim Biological Activity

Description Ormetoprim is a veterinary antimicrobial which commonly used in aquaculture and poultry industries. Ormetoprim can be used to prevent the spread of disease in freshwater aquaculture and promote growth in farm animals[1][2].
Related Catalog
In Vivo Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL)[3]. Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration[3]. Animal Model: Hybrid striped bass (565-805 g)[3] Dosage: 50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis) Administration: I.p. and p.o. administration Result: I.p.: t1/2(elim)=7.5 h; t1/2(abs)=5.4 h; Cmax=1.2 μg/mL. P.o.: t1/2(elim)=3.9 h; t1/2(abs)=3.9 h; Cmax=1.6 μg/mL; F=78.5%.
References

[1]. Sanders SM, et, al. Sorption of the veterinary antimicrobials sulfadimethoxine and ormetoprim in soil. J Environ Qual. 2008 Jun 23; 37(4): 1510-8.

[2]. Guerard JJ, et, al. Photodegradation of ormetoprim in aquaculture and stream-derived dissolved organic matter. J Agric Food Chem. 2012 Oct 3; 60(39): 9801-6.

[3]. Bakal RS, et, al. Pharmacokinetics of sulfadimethoxine and ormetoprim in a 5:1 ratio following intraperitoneal and oral administration, in the hybrid striped bass (Morone chrysops x Morone saxitalis). J Vet Pharmacol Ther. 2004 Feb; 27(1): 1-6.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 398.2±52.0 °C at 760 mmHg
Melting Point 233°C
Molecular Formula C14H18N4O2
Molecular Weight 274.318
Flash Point 194.6±30.7 °C
Exact Mass 274.142975
PSA 96.28000
LogP 1.13
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.608
Storage condition 0-6°C

 Synonyms

UNII-M3EFS94984
5-((4,5-Dimethoxy-2-methylphenyl)methyl)-2,4-pyrimidinediamine
Ro 5-9754
component of Rofenaid
Ormetoprim
EINECS 230-246-6
MFCD00057747
2,4-Pyrimidinediamine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]-
5-(4,5-Dimethoxy-2-methylbenzyl)-2,4(1H,3H)-pyrimidinediimine
5-(4,5-Dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine
2,4(1H,3H)-Pyrimidinediimine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]-
5-(4,5-Dimethoxy-2-methylbenzyl)-2,4-pyrimidinediamine
Ormethoprim
Ormetorprim
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