Swertiajaponin

Modify Date: 2025-08-25 19:40:38

Swertiajaponin Structure
Swertiajaponin structure
Common Name Swertiajaponin
CAS Number 6980-25-2 Molecular Weight 462.404
Density 1.6±0.1 g/cm3 Boiling Point 761.3±60.0 °C at 760 mmHg
Molecular Formula C22H22O11 Melting Point N/A
MSDS N/A Flash Point 266.6±26.4 °C

 Use of Swertiajaponin


Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity[1].

 Names

Name swertiajaponin
Synonym More Synonyms

 Swertiajaponin Biological Activity

Description Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity[1].
Related Catalog
Target

IC50: 43.47 μM (tyrosinase)[1]

References

[1]. Lee B, et al. Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase. Oncotarget. 2017 Sep 15;8(56):95530-95541.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 761.3±60.0 °C at 760 mmHg
Molecular Formula C22H22O11
Molecular Weight 462.404
Flash Point 266.6±26.4 °C
Exact Mass 462.116211
PSA 190.28000
LogP 1.83
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.717
InChIKey DLVLXOYLQKCAME-DGHBBABESA-N
SMILES COc1cc2oc(-c3ccc(O)c(O)c3)cc(=O)c2c(O)c1C1OC(CO)C(O)C(O)C1O
Storage condition 2-8℃

 Synonyms

Swertiajaponin
D-Glucitol, 1,5-anhydro-1-C-[2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-6-yl]-, (1S)-
(1S)-1,5-Anhydro-1-[2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4-oxo-4H-chromen-6-yl]-D-glucitol
Leucanthoside
2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
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