Sorbinil
Modify Date: 2024-01-03 10:04:44
Sorbinil structure
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Common Name | Sorbinil | ||
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| CAS Number | 68367-52-2 | Molecular Weight | 236.19900 | |
| Density | 1.52g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C11H9FN2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of SorbinilSorbinil, is an Aldose reductase inhibitor (ARI).Sorbinil plays therapeutic role in treating diabetes and diabetic complications, decreases AR activity and inhibits polyol pathway, it to be found comparatively safer than other ARIs for human use[1]. |
| Name | sorbinil |
|---|---|
| Synonym | More Synonyms |
| Description | Sorbinil, is an Aldose reductase inhibitor (ARI).Sorbinil plays therapeutic role in treating diabetes and diabetic complications, decreases AR activity and inhibits polyol pathway, it to be found comparatively safer than other ARIs for human use[1]. |
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| Related Catalog | |
| References |
| Density | 1.52g/cm3 |
|---|---|
| Molecular Formula | C11H9FN2O3 |
| Molecular Weight | 236.19900 |
| Exact Mass | 236.06000 |
| PSA | 67.43000 |
| LogP | 1.30050 |
| Index of Refraction | 1.629 |
| Storage condition | 2-8°C |
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The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.
PLoS ONE 7(4) , e31399, (2012) Diabetes mellitus is recognized as a leading cause of new cases of blindness. The prevalence of diabetic eye disease is expected to continue to increase worldwide as a result of the dramatic increase ... |
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Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.
Invest. Ophthalmol. Vis. Sci. 55(5) , 2853-61, (2014) Retinal microglia become activated in diabetes and produce pro-inflammatory molecules associated with changes in retinal vasculature and increased apoptosis of retinal neurons and glial cells. We soug... |
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Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells.
Chem. Biol. Interact. 234 , 254-60, (2015) Chronic hyperglycemia is an important risk factor involved in the onset and progression of diabetic retinopathy (DR). Among other effectors, aldose reductase (AR) has been linked to the pathogenesis o... |
| (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione |
| Sorbinil |
| Sorbinilo |
| Sorbinilum |