Astressin 2B

Modify Date: 2025-08-25 10:51:42

Astressin 2B structure	Common Name	Astressin 2B
	CAS Number	681260-70-8	Molecular Weight	4041.69000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈₃H₃₀₇N₄₉O₅₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Astressin 2B

Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying[1][2][3].

Name	Astressin2B trifluoroacetate salt
Synonym	More Synonyms

Description	Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Others
References	[1]. Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem. 2002;45(21):4737-4747. [2]. Hoare SR, et al. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides. 2005;26(3):457-470. [3]. Henry B, et al. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci. 2006;26(36):9142-9152.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR

Research Areas >> Others

References

[1]. Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem. 2002;45(21):4737-4747.

[2]. Hoare SR, et al. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides. 2005;26(3):457-470.

[3]. Henry B, et al. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci. 2006;26(36):9142-9152.

Molecular Formula	C₁₈₃H₃₀₇N₄₉O₅₃
Molecular Weight	4041.69000
Exact Mass	4039.28000
PSA	1686.63000
LogP	10.19370

Safety Phrases	22-24/25

Astressin 2B

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Astressin 2B

Use of Astressin 2B

Names

Astressin 2B Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.